Will help you to backup USB drive in easy and quick way. BackUpAnywhere is portable programm that will help you to backup usb drive in easy and quick way.
For the first time you will be asked to give a path to the directory u want you usb drive to be backuped to
and for the all other times you can just sync your files (and of course backup them if needed).

The license of this software is Free, you can free download and free use this data backup software.