Malin (Maximum Likelihood Analysis of Intron Evolution) is a software package for the analysis of eukaryotic gene structure evolution. It provides a graphical user interface for various tasks commonly used to infer the evolution of exon-intron structure in protein-coding orthologs. The implemented tasks include the following.
1. Identification of homologous splice sites in annotated protein sequence alignments.
2. Computation of primary statistics about introns in homologous sites ("shared introns").
3. Estimation of ancestral intron content, intron losses and gains by Dollo parsimony.
4. Estimation of intron loss and gain rates in a probabilistic model.
5. Estimation of ancestral intron content, intron losses and gains in a probabilistic model.
6. Inference of evolutionary histories at individual sites.
7. Error estimation for rates and histories by bootstrap.

MALIN operates with sessions: each session is associated with a fixed species phylogeny. More than one session may be open at one time: e.g., the same data set may be analyzed with different phylogenies simultaneously. A session has three main components, represented by the tabs of the displayed workspace: a species phylogeny (Tree), a browser for data sets and analysis results (Data) and a browser for probabilistic models (Rates).

Requirements:
* Java

The license of this software is Free, you can free download and free use this cad software.