Nucleotide polymorphism analysis made easy. DnaSP (DNA Sequence Polymorphism), is a software package for the analysis of nucleotide polymorphism from aligned DNA sequence data. DnaSP can estimate several measures of DNA sequence variation within and between populations (in noncoding, synonymous or nonsynonymous sites, or in various sorts of codon positions), as well as linkage disequilibrium, recombination, gene flow and gene conversion parameters. DnaSP can also carry out several tests of neutrality: Hudson, Kreitman and Aguad (1987), Tajima (1989), McDonald and Kreitman (1991), Fu and Li (1993), and Fu (1997) tests. Additionally, DnaSP can estimate the confidence intervals of some test-statistics by the coalescent. The results of the analyses are displayed on tabular and graphic form.

DnaSP can not align sequences. There are some available programs that can do this. For example, you can perform the multiple alignment with CLUSTAL W (Thompson et al. 1994). This program produces an output (multiple aligned sequences in NBRF/PIR format) that can be read by DnaSP.

Please Note: this program is free for academic and non-comercial use.

Requirements:
* Java

The license of this software is Freeware, you can free download and free use this calculator software.