Build a relational database integrating, in a phylogenetic framework. MANTiS is an application system that: builds a relational database integrating, in a phylogenetic framework, all Ensembl genes, corresponding PANTHER molecular functions and biological processes, as well as GNF, e-genetics, and HMDEG expression data; makes extensively use of the Ensembl ortholog/paralog prediction pipeline for identifying gene duplication events; and implements a dynamical programming approach for the mapping of gene gains, duplications, and losses on the phylogenetic tree.

Connection to the MANTiS database
The MANTiS interface (available for Windows, Mac OSX, and Linux at www.mantisdb.org) connects to a MySQL database running on a server in the Laboratory of Artificial and Natural Evolution (LANE) in the Dpt of Zoology & Animal Biology at the University of Geneva (Switzerland). It requires a connection through the port 3306. This port might be blocked by a firewall, so ask your network administrator to unblock it for your machine, if necessary.

Through a user-friendly interface, MANTiS allows the user to identify
1.gains and losses on specific branches of the tree,
2.genome content of ancestral species,
3.statistically over- or under-represented molecular functions, biological processes and anatomical systems (expression data), and
4.tissue specificity of gained, duplicated, and lost genes.

Finally, the entire set of information available in MANTiS can be exploited further using an advanced system of queries by which gene identity, mapping, and function parameters can be combined using logical operators.

Requirements:
* Java

The license of this software is Freeware, you can free download and free use this calculator software.