Fit blood time-activity curve with this program. fit_winp can fit blood time-activity curve (TAC) from PET [O-15]H2O study to a six or four parameter function, when radiowater is given to patient as a short infusion.

Command-line arguments:
1) Plasma TAC filename
2) Filename for fitted function parameters (optional)

Plasma data (3) must contain two columns: sample times and (radioactivity) concentrations which preferably are corrected for physical decay and circulating metabolites. Extra columns are ignored. Function parameters will be written in the parameter file (4); note that these describe dispersion corrected curve, if dispersion time constants are specified.

Command-line options:
-tau1=<Dispersion time constant (s)>
-tau2=<2nd dispersion time constant (s)>
Dispersion (5) is added to function, also to saved curve and plot
-func=<331|332>
Select the function to be fitted; 331 is the default
-MRL
Error is returned if MRL check is not passed
-fast or -safe
Speed up the fitting but increase the chance of failure, or increase the reliability at the cost of computing time
-wf
Weight by sampling interval
-fit=<Filename>
Fitted TAC is written in DFT format
-dcfit=<Filename>
Fitted dispersion corrected (5) TAC is written in DFT format; can only be used when dispersion time constant is set
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing
Options for constraining the fit:
-Ti=<infusion time>
Duration of tracer infusion; 0, if short bolus
-Ta=<appearance time>
Time when tracer concentration starts ascending.

The license of this software is Freeware, you can free download and free use this calculator software.