Non-linear fitting made easy. fitk2 help you with non-linear fitting of one-tissue compartment model to plasma and tissue time-activity curves (TACs) to estimate K1, k2 and Vb.

Parameters:
1) Plasma file (corrected for labeled metabolites)
2) Blood file
3) Tissue TAC file (*.dft)
4) Fit end time (duration)
5) Result file

Options:
-lim[=<filename>]
Specify the constraints for model parameters; This file with default values can be created by giving this option as the only command-line argument to this program. Without filename the default values are printed on screen.
-SD[=<y|N>]
Standard deviations are calculated and saved in results (Y, default), or not calculated (n). Program runs a lot faster if SD and CL are not calculated.
-CL[=<y|N>]
95% Confidence limits are calculated and saved in results (y), or not calculated (N, default).
-Vb=<Vb(%)>
Enter a fixed Vb; fitted by default.
-<BPnd|BPp|DVR>=<Reference region name or filename>
Optional reference region is used to calculate BPnd, BPp, or DVR; BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.

The license of this software is Freeware, you can free download and free use this calculator software.