Fit compartmental model with this program. lhsol help you with the fitting of full or reduced compartmental model to plasma and tissue time-activity curves (TACs) to estimate the model parameters.
Compartmental models are transformed into general linear least squares functions, which are solved using Lawson-Hanson non-negative least squares (NNLS) algorithm.
Linear parameters are always >=0, but compartmental model parameters may get negative estimates. Note that rate constants and macroparameters are represented per volume (measured by PET) including vascular volume.

Usage: lhsol <Model> <Plasma file> <Tissue file> <Fit time> <Result file>

, where Model is one of these strings:
k1 (for assuming k2=k3=k4=k5=k6=0)
k2 (for assuming k3=k4=k5=k6=0)
k3 (for assuming k4=k5=k6=0)
k4 (for assuming k5=k6=0)
k5s (for assuming k6=0 and compartments in series)
k6s (compartments in series)
k5p (for assuming k6=0 and compartments in parallel)
For model 'k6p' many of model parameters could not be solved.

Options:
-Vp=<ignored|fitted>
Vp is ignored (default) or fitted; note that plasma curve is assumed to represent vascular blood curve, which is usually not true.
-w1 | -wf
Sample weights are set to 1 (-w1) or to frame lengths (-wf); by default weights in tissue data file are used, if available.
-mid[=<y|N>]
Mid frame times are used (y) or not used (n, default) even if frame start and end times are available.
-fit=<Filename>
Fitted regional TACs are written in DFT format.
-svg=<Filename>
Fitted and measured TACs are plotted in specified SVG file.
-par=<Filename>
Parameters of linear model are saved in result format.
-h or --help
Print this message and exit.
--version or --build
Print software build information and exit.
--silent
Program works silently, printing only error and warning messages.
--verbose
Program prints more information about what it is doing.

The license of this software is Freeware, you can free download and free use this calculator software.