Estimate the elimination rate constant of a PET tracer can estimate the half-life (t1/2) and elimination rate constant (kEL) of a PET tracer in plasma, and the AUC of plasma time-activity curve from 0 to infinite time.
The natural logarithm of tracer concentration is plotted against time from bolus infusion. The plot becomes linear in the end phase, as the tracer is eliminated according to the laws of first-order reaction kinetics. The slope of the linear part of the plot equals -kEL.

Usage: paucinf <Plasmafile> [Result file]

Options:
-end=<sample time>
Use data from 0 to given time in the line fit; by default search for the best line fit extends to the last sample
-start=<sample time>
Use data from given time to end in the line fit; by default, the search for the best line fit extends to the first sample
-winnonlin
Best line fit is searched using algorithm that gives similar results to WinNonlin with the same simple model
-svg=<Filename>
Plots of log transformed TACs and fitted lines are written in specified file in Scalable Vector Graphics (SVG) 1.1 format; specification in www.w3.org/TR/SVG/
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.

The license of this software is Freeware, you can free download and free use this calculator software.